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Home / Primary Antibodies / Polyclonal Antibodies

STT3B antibody

SKU : BHA10808348

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Mfr.No.	FNab08356
Alternative Names	SIMP
Categories	Primary Antibodies
Clonality	polyclonal
Description	Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient cotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL- TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.
Host	Rabbit
Immunogen	STT3, subunit of the oligosaccharyltransferase complex, homolog B
Isotype	IgG
Molecular Weight	94 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	SIMP, STT3 B, STT3B

Uniprot	Q8TCJ2
Gene Id	201595
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:1000-1:4000; IHC: 1:50-1:500

Manual	FNab08356.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808348	FNab08356	100ug	$260		Add to Cart

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