Suppression of tumorigenicity protein 18; Zinc finger protein 387; ST18; KIAA0535; ZNF387
Categories
Primary Antibodies
Clonality
polyclonal
Description
Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters By similarity. Inhibits colony formation in cultured breast cancer cells.Nagase T., DNA Res. 5:31-39(1998).The MGC Project Team, Genome Res. 14:2121-2127(2004).Jandrig B., Oncogene 23:9295-9302(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from N-terminal of Human ZNF387.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters By similarity. Inhibits colony formation in cultured breast cancer cells.
Nagase T., DNA Res. 5:31-39(1998). The MGC Project Team, Genome Res. 14:2121-2127(2004). Jandrig B., Oncogene 23:9295-9302(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ZNF387 protein.
Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.
Protein Families
MYT1 family
Tissue Specificity
Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.