Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau(By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida(By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis(PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9(PubMed:10500252).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252).
Host
Rabbit
Immunogen
sperm associated antigen 8
Isotype
IgG
Molecular Weight
56-65 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Uniprot
Q99932
Gene Id
26206
Research Area
Stem Cells
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)