Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206(By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal(By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation(By similarity).
Clonality
monoclonal
Host
Mouse
Immunogen
SRY(sex determining region Y)-box 2
Immunogen Region
SRY(seX determining region Y)-boX 2
Isotype
IgG1
Molecular Weight
34kd
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:50-1:200
Synonyms
ANOP3, MCOPS3, SOX2, Transcription factor SOX 2
Uniprot
P48431
Gene Id
6657
Clone No
1B5
Research Area
Epigenetics, Stem Cells, Metabolism, Neuroscience
Form
liquid
Purification
protein A+G purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:50-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10148.pdf" target="_blank">Data Sheet</ a>