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Home / Primary Antibodies / Polyclonal Antibodies

SOD (EC) Antibody - SPC-124

BHA11906603
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Swissprot P08294
Accession Number P08294
Gene Id 6649
Target SOD3
Research Area Cancer, Oxidative Stress, Neurodegeneration, ALS Disease, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Scientific Background Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2, 5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are three types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (6). SOD3 can also be distinguished by its heparin-binding capacity (1).
Shipping Temperature Blue Ice or 4°C
Specificity Detects extracellular SOD ~35kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications WB, ICC/IF
Description WB ; ICC ; IF
Dilution WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Adachi T., et al. (1992) Clin Chim Acta. 212: 89-102.

2. Barrister J.V., et al. (1987). Crit. Rev. Biochem. 22:111-180.

3. FurukawaY., and O'Halloran T. (2006) Antioxidants & Redo Signaling. 8(5): 6.

4. Gao B., et al. (2003) Am J Physiol Lung Cell Mol Physiol 284: L917-L925.

5. Hassan H.M. (1988) Free Radical Biol. Med. 5: 377-385.

6. Wispe J.R., et al. (1989) BBA. 994: 30-36.

7. Regan, E. et al. (2005) Arthritis & Rheumatism 52(11): 3479–3491
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11906603-1 SPC-124D Unconjugated 100 ug $322
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BHA11906603-2 SPC-124D-A390 ATTO 390 100 ug $425
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BHA11906603-3 SPC-124D-A488 ATTO 488 100 ug $421
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BHA11906603-4 SPC-124D-A594 ATTO 594 100 ug $421
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BHA11906603-5 SPC-124D-ALP Alkaline Phosphatase 100 ug $408
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BHA11906603-6 SPC-124D-APC APC 100 ug $419
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BHA11906603-7 SPC-124D-BI Biotin 100 ug $410
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BHA11906603-8 SPC-124D-FITC FITC 100 ug $403
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BHA11906603-9 SPC-124D-HRP HRP 100 ug $396
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BHA11906603-10 SPC-124D-PCP PerCP 100 ug $419
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BHA11906603-11 SPC-124D-RPE RPE 100 ug $413
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BHA11906603-12 SPC-124S Unconjugated 12 ug $44
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