E3 ubiquitin-protein ligase RNF138; EC 6.3.2.-; RING finger protein 138; Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein
Antigen
RNF138
Categories
Primary Antibodies
Clonality
polyclonal
Description
E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.Wang L., Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.Ota T., Nat. Genet. 36:40-45(2004).Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human RNF138.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
Wang L., Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. Ota T., Nat. Genet. 36:40-45(2004). Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total RNF138 protein.