Replication factor C subunit 2; Activator 1 subunit 2; Replication factor C 40 kDa subunit; RF-C 40 kDa subunit; RFC40
Antigen
RFC2
Categories
Primary Antibodies
Clonality
polyclonal
Description
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP By similarity.Chen M., Proc. Natl. Acad. Sci. U.S.A. 89:2516-2520(1992).Hurwitz J., Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.Martindale D.W., Mamm. Genome 11:890-898(2000).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human RFC2.
Involvement In Disease
RFC2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region (PubMed:11003705).
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP By similarity.
Chen M., Proc. Natl. Acad. Sci. U.S.A. 89:2516-2520(1992). Hurwitz J., Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases. Martindale D.W., Mamm. Genome 11:890-898(2000).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total RFC2 protein.
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).
Pathway
DNA repair pathway
Protein Families
Activator 1 small subunits family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.