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Home / Primary Antibodies / Polyclonal Antibodies

RBPJ antibody

SKU : BHA10807187

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Mfr.No.	FNab07195
Alternative Names	IGKJRB ; IGKJRB1 ; RBPJK ; RBPSUH
Background	The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788).
Host	Rabbit
Immunogen	recombination signal binding protein for immunoglobulin kappa J region
Isotype	IgG
Molecular Weight	55 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	IGKJRB, IGKJRB1, RBPJK, RBPSUH

Uniprot	Q06330
Gene Id	3516
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP
Description	ELISA ; WB ; IHC ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:50

Manual	FNab07195.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807187	FNab07195	100ug	$260		Add to Cart

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