Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Host
Rabbit
Immunogen
Ras association(RalGDS/AF-6) domain family(N-terminal) member 7
Isotype
IgG
Molecular Weight
40 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
C11orf13, HRC1
Uniprot
Q02833
Gene Id
8045
Research Area
Signal Transduction
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)