Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Function
Cardiovascular Disease
Isotype
IgG
Pair Information
N/D
Shape
Liquid
Research Area
Cardiovascular Disease
Form
Liquid
Purity
>95% by Caprylic Acid Ammonium Sulfate Precipitation
Storage
Shipped at 4°C Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Storage Condition
Aliquot and store at -20 or -80 deg C. Avoid repeated freeze/thaw cycles
Applications
CLIA
Tested Application
CLIA
Reference
[1]"Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005). [2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14:2121-2127(2004) . [3]"Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis."Samanta U., Bahnson B.J.J. Biol. Chem. 283:31617-31624(2008).
Reviews of Rabbit anti-human Platelet-activating factor acetylhydrolase(Lp-PLA2)polyclonal Antibody