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Home / Primary Antibodies / Polyclonal Antibodies

RAB5A antibody

SKU : BHA10807030

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Mfr.No.	FNab07038
Alternative Names	RAB5
Background	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes(PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension(PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan(PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3(By similarity).
Categories	Primary Antibodies
Clonality	polyclonal
Description	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell- containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Host	Rabbit
Immunogen	RAB5A, member RAS oncogene family
Isotype	IgG
Molecular Weight	24 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	RAB5, RAB5A, Ras related protein Rab 5A

Uniprot	P20339
Gene Id	5868
Research Area	Signal Transduction, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, WB, IP
Description	ELISA ; IHC ; WB ; IP
Tested Application	WB: 1:200-1:2000; IP:1:200-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500

Manual	FNab07038.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807030	FNab07038	100ug	$240		Add to Cart

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