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Home / Primary Antibodies / Polyclonal Antibodies

PKM2-specific antibody

SKU : BHA10806487

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Mfr.No.	FNab06495
Background	PKM2, also named as OIP3, PK2, PK3, PKM, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM2 plays a general role in caspase independent cell death of tumor cells. The activity of the M2 isoform (but not the M1 isoform) can be inhibited by tyrosine kinase signalling in tumourcells.The primary pyruvate kinase isoform before tumour development is PK-M1; however, the primary isoform from four independent tumours is PK-M2.(PMID:18337823) PKM2, Pyruvate kinase isozymes M1/M2, has 2 isoforms .The immunogen of this antibody is M2 isoform, also called PKM2. This antibody is specific to PKM2 isoform.
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	PKM2 pyruvate kinase, muscle
Isotype	IgG
Molecular Weight	58 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	CTHBP, OIP 3, OIP3, Opa interacting protein 3, p58, PK2, PK3, PKM, PKM2, PK-M2, PKM2 pyruvate kinase, muscle, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle isozyme, TCB, THBP1, Tumor M2 PK

Uniprot	P14618
Research Area	Stem Cells, Cancer, Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, IP
Description	ELISA ; WB ; IHC ; IF ; IP
Tested Application	WB: 1:1000-1:4000; IP: 1:200-1:1000; IHC: 1:100-1:400; IF: 1:10-1:100

Manual	FNab06495.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806487	FNab06495	100ug	$260		Add to Cart

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