JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.
Loding Loading ....
Home / Primary Antibodies / Monoclonal Antibodies

PINK1 Antibody, Clone S4-15 - SMC-450

BHA11904457
Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Request More Infos
Order Now

Credit card payments now incur a 3% fee.

Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
Request More Infos
Sample Request
Swissprot Q9BXM7.1
Accession Number NP_115785.1
Gene Id 65018
Target PINK1
Clone No S4-15
Research Area Cell Signaling, Post-translational Modifications, Phosphorylation, Cardiovascular System, Heart, Neurodegeneration, Parkinson's Disease, Neuroscience
Buffer PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background PINK1 (PTEN induced putative kinase 1) is a mitochondrial serine/threonine kinase which maintains mitochondrial function/integrity, provides protection against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins, and is involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). PINK1 is synthesized as a 63 kD protein which undergoes proteolyt processing to generate at least two cleaved forms (55 kD and 42 kD). PINK1 and its substrates have been found in the cytosol as well as in different sub-mitochondrial compartments, and according to the recent reports; PINK1 may be targeted to OMM (outer mitochondrial membrane) with its kinase domain facing the cytosol, providing a possible explanation for the observed physical interaction with the cytosolic E3 ubiquitin ligase Parkin.
Defective PINK1 may cause alterations in processing, stability, localization and activity as well as binding to substrates/interaction-partners which ultimately leads to differential effects on mitochondrial function and morphology. Mutations in PINK1 are linked to autosomal recessive early onset Parkinson's disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of alpha-synuclein, as well as proteasome dysfunction.
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~50kDa.
Storage -20ºC
Storage Buffer PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, WB, ICC/IF
Description WB ; IHC ; ICC ; IF
Dilution WB (1:1000); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11904457-1 SMC-450D Unconjugated 100 ug $330
Add to Cart
BHA11904457-2 SMC-450D-A390 ATTO 390 100 ug $384
Add to Cart
BHA11904457-3 SMC-450D-A488 ATTO 488 100 ug $383
Add to Cart
BHA11904457-4 SMC-450D-A594 ATTO 594 100 ug $383
Add to Cart
BHA11904457-5 SMC-450D-ALP Alkaline Phosphatase 100 ug $376
Add to Cart
BHA11904457-6 SMC-450D-APC APC 100 ug $382
Add to Cart
BHA11904457-7 SMC-450D-BI Biotin 100 ug $378
Add to Cart
BHA11904457-8 SMC-450D-FITC FITC 100 ug $374
Add to Cart
BHA11904457-9 SMC-450D-HRP HRP 100 ug $370
Add to Cart
BHA11904457-10 SMC-450D-PCP PerCP 100 ug $382
Add to Cart
BHA11904457-11 SMC-450D-RPE RPE 100 ug $380
Add to Cart
BHA11904457-12 SMC-450S Unconjugated 12 ug $44
Add to Cart