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Home / Primary Antibodies

PIKFYVE Antibody

SKU : BHA10559371

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA072525
Alternative Names	1-phosphatidylinositol-4-phosphate 5-kinase; EC 2.7.1.68; FYV1; FYVE finger-containing phosphoinositide kinase; KIAA0981
Categories	Primary Antibodies
Clonality	polyclonal
Description	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.Ota T., Nat. Genet. 36:40-45(2004).Sbrissa D., J. Biol. Chem. 277:6073-6079(2002).Brill L.M., Anal. Chem. 76:2763-2772(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human PIP5K.
Involvement In Disease	Corneal dystrophy, fleck (CFD)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes. Ota T., Nat. Genet. 36:40-45(2004). Sbrissa D., J. Biol. Chem. 277:6073-6079(2002). Brill L.M., Anal. Chem. 76:2763-2772(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PIP5K protein.
Subcellular Location	Endosome membrane

Uniprot	Q9Y2I7
Database Links	HGNC:23785 OMIM:121850 KEGG:hsa:200576 STRING:9606.ENSP00000264380 UniGene:Hs.744997
Function	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.
Pathway	Regulation of actin cytoskeleton Phosphatidylinositol signaling system

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559371	CSB-PA072525	100ul	$297		Add to Cart

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