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Home / Primary Antibodies / Polyclonal Antibodies

Phosphoserine Antibody - SPC-149

BHA11906773
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
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Target Phosphoserine
Research Area Cell Signaling, Post-translational Modifications, Phosphorylation
Buffer PBS, 50% glycerol, 0.01% sodium azide
Concentration 0.25 mg/ml
Dilutions WB (1:500), ICC/IF (1:50), ELISA (1:250), IP (1:100); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Scientific Background Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein's activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time (1). Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders (2-4).
Shipping Temperature Blue Ice or 4°C
Specificity Detects proteins phosphorylated on serine residues. Does not cross-react with phosphotyrosine.
Storage -20ºC
Storage Buffer PBS, 50% glycerol, 0.01% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications ELISA, IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP ; ELISA
Dilution WB (1:500), ICC/IF (1:50), ELISA (1:250), IP (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
Conjugate Datasheet
SDS
Reference 1. Goto H. et al. (2005) Nature Cell Biology 8: 180-187.

2. Blume-Jensen P. and Hunter T. (2001) Nature 411: 355-365.

3. Downward J. (2001) Nature 411: 759-762.

4. Pawson T. and Saxton T.M. (1999) Cell 97: 675-678.

5. Ostrovsky P.C. (1995) Genes Dev. 9(16): 2034-2041.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11906773-1 SPC-149F Unconjugated 400 ul $341
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BHA11906773-2 SPC-149F-A390 ATTO 390 400 ul $395
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BHA11906773-3 SPC-149F-A488 ATTO 488 400 ul $394
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BHA11906773-4 SPC-149F-A594 ATTO 594 400 ul $394
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BHA11906773-5 SPC-149F-BI Biotin 400 ul $389
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BHA11906773-6 SPC-149F-FITC FITC 400 ul $385
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