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Home / Primary Antibodies

Phospho-XIAP (Ser87) Antibody

SKU : BHA10560118

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA548634
Alternative Names	API3; BIR4; BIRC4; IAP3; X-linked IAP
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Huang X, Wu Z, Mei Y, Wu M (2013)EMBO J 32, 2204-16. Bornhauser BC, et al. (2007) Blood 110, 2084-91.Dan HC, et al. (2004)J Biol Chem 279, 5405-12.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine87(K-V-S(p)-P-N) derived from Human XIAP .
Involvement In Disease	Lymphoproliferative syndrome, X-linked, 2 (XLP2)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Huang X, Wu Z, Mei Y, Wu M (2013)EMBO J 32, 2204-16. Bornhauser BC, et al. (2007) Blood 110, 2084-91.Dan HC, et al. (2004)J Biol Chem 279, 5405-12.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of XIAP only when phosphorylated at serine 87.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P98170
Database Links	HGNC:592 OMIM:300079 KEGG:hsa:331 STRING:9606.ENSP00000347858 UniGene:Hs.356076
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include
Pathway	Focal adhesion NF-kappa B signaling pathway Apoptosis Necroptosis Ubiquitin mediated proteolysis NOD-like receptor signaling pathway
Protein Families	IAP family
Tissue Specificity	Ubiquitous, except peripheral blood leukocytes.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560118	CSB-PA548634	100ul	$360		Add to Cart

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