Phospho-VEGFR1 (Tyr1213) Antibody

Mfr.No.	AF3204
Alternative Names	EC 2.7.10.1 ; FLT 1 ; FLT ; Flt-1 ; FLT1 ; Fms like tyrosine kinase 1 ; Fms related tyrosine kinase 1 ; Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) ; Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor ; Fms-like tyrosine kinase 1 ; FRT ; Soluble VEGF receptor 1 14 ; Soluble VEGFR1 variant 2 ; Soluble VEGFR1 variant 21 ; Tyrosine protein kinase FRT ; Tyrosine protein kinase receptor FLT ; Tyrosine-protein kinase FRT ; Tyrosine-protein kinase receptor FLT ; Vascular endothelial growth factor receptor 1 ; Vascular endothelial growth factor vascular permeability factor receptor ; Vascular permeability factor receptor 1 ; Vascular permeability factor receptor ; VEGFR 1 ; VEGFR-1 ; VEGFR1 ; VGFR1_HUMAN ;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.
Immunogen	A synthesized peptide derived from human VEGFR1 around the phosphorylation site of Tyrosine 1213.
Molecular Weight	Observed Mol.Wt.: 151 kDa. Predicted Mol.Wt.: 151kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-VEGFR1 (Tyr1213) Antibody detects endogenous levels of VEGFR1 only when phosphorylated at Tyrosine 1213.
Subcellular Location	Secreted and Cell membrane.

Uniprot

P17948

Gene Id

2321

Sequence

10	20	30	40	50
MVSYWDTGVL	LCALLSCLLL	TGSSSGSKLK	DPELSLKGTQ	HIMQAGQTLH
60	70	80	90	100
LQCRGEAAHK	WSLPEMVSKE	SERLSITKSA	CGRNGKQFCS	TLTLNTAQAN
110	120	130	140	150
HTGFYSCKYL	AVPTSKKKET	ESAIYIFISD	TGRPFVEMYS	EIPEIIHMTE
160	170	180	190	200
GRELVIPCRV	TSPNITVTLK	KFPLDTLIPD	GKRIIWDSRK	GFIISNATYK
210	220	230	240	250
EIGLLTCEAT	VNGHLYKTNY	LTHRQTNTII	DVQISTPRPV	KLLRGHTLVL
260	270	280	290	300
NCTATTPLNT	RVQMTWSYPD	EKNKRASVRR	RIDQSNSHAN	IFYSVLTIDK
310	320	330	340	350
MQNKDKGLYT	CRVRSGPSFK	SVNTSVHIYD	KAFITVKHRK	QQVLETVAGK
360	370	380	390	400
RSYRLSMKVK	AFPSPEVVWL	KDGLPATEKS	ARYLTRGYSL	IIKDVTEEDA
410	420	430	440	450
GNYTILLSIK	QSNVFKNLTA	TLIVNVKPQI	YEKAVSSFPD	PALYPLGSRQ
460	470	480	490	500
ILTCTAYGIP	QPTIKWFWHP	CNHNHSEARC	DFCSNNEESF	ILDADSNMGN
510	520	530	540	550
RIESITQRMA	IIEGKNKMAS	TLVVADSRIS	GIYICIASNK	VGTVGRNISF
560	570	580	590	600
YITDVPNGFH	VNLEKMPTEG	EDLKLSCTVN	KFLYRDVTWI	LLRTVNNRTM
610	620	630	640	650
HYSISKQKMA	ITKEHSITLN	LTIMNVSLQD	SGTYACRARN	VYTGEEILQK
660	670	680	690	700
KEITIRDQEA	PYLLRNLSDH	TVAISSSTTL	DCHANGVPEP	QITWFKNNHK
710	720	730	740	750
IQQEPGIILG	PGSSTLFIER	VTEEDEGVYH	CKATNQKGSV	ESSAYLTVQG
760	770	780	790	800
TSDKSNLELI	TLTCTCVAAT	LFWLLLTLFI	RKMKRSSSEI	KTDYLSIIMD
810	820	830	840	850
PDEVPLDEQC	ERLPYDASKW	EFARERLKLG	KSLGRGAFGK	VVQASAFGIK
860	870	880	890	900
KSPTCRTVAV	KMLKEGATAS	EYKALMTELK	ILTHIGHHLN	VVNLLGACTK
910	920	930	940	950
QGGPLMVIVE	YCKYGNLSNY	LKSKRDLFFL	NKDAALHMEP	KKEKMEPGLE
960	970	980	990	1000
QGKKPRLDSV	TSSESFASSG	FQEDKSLSDV	EEEEDSDGFY	KEPITMEDLI
1010	1020	1030	1040	1050
SYSFQVARGM	EFLSSRKCIH	RDLAARNILL	SENNVVKICD	FGLARDIYKN
1060	1070	1080	1090	1100
PDYVRKGDTR	LPLKWMAPES	IFDKIYSTKS	DVWSYGVLLW	EIFSLGGSPY
1110	1120	1130	1140	1150
PGVQMDEDFC	SRLREGMRMR	APEYSTPEIY	QIMLDCWHRD	PKERPRFAEL
1160	1170	1180	1190	1200
VEKLGDLLQA	NVQQDGKDYI	PINAILTGNS	GFTYSTPAFS	EDFFKESISA
1210	1220	1230	1240	1250
PKFNSGSSDD	VRYVNAFKFM	SLERIKTFEE	LLPNATSMFD	DYQGDSSTLL
1260	1270	1280	1290	1300
ASPMLKRFTW	TDSKPKASLK	IDLRVTSKSK	ESGLSDVSRP	SFCHSSCGHV
1310	1320	1330
SEGKRRFTYD	HAELERKIAC	CSPPPDYNSV	VLYSTPPI

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.