Phospho-TrkA /TrkB (Tyr785/Tyr816) Antibody

Mfr.No.	AF4390
Alternative Names	gp140trk ; High affinity nerve growth factor receptor ; High affinity nerve growth factor receptor precursor ; MTC ; Neurotrophic tyrosine kinase receptor type 1 ; NTRK1 ; NTRK1_HUMAN ; Oncogene TRK ; p14-TrkA ; p140 TrkA ; p140-TrkA ; Slow nerve growth ; Trk A ; TRK ; Trk-A ; TRK1 ; TRK1-transforming tyrosine kinase protein ; Tropomyosin-related kinase A ; Tyrosine kinase receptor A ; Tyrosine kinase receptor ;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Immunogen	A synthesized peptide derived from human TrkA around the phosphorylation site of Tyr785.
Molecular Weight	Observed Mol.Wt.: 87kDa. Predicted Mol.Wt.: 88kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-TrkA (Tyr785) /TrkB (Tyr816) Antibody detects endogenous levels of TrkA only when phosphorylated at Tyr785.
Subcellular Location	Cell membrane. Early endosome membrane. Late endosome membrane. Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity).

Uniprot

P04629

Gene Id

4914

Sequence

10 20 30 40 50
MLRGGRRGQL GWHSWAAGPG SLLAWLILAS AGAAPCPDAC CPHGSSGLRC
60 70 80 90 100
TRDGALDSLH HLPGAENLTE LYIENQQHLQ HLELRDLRGL GELRNLTIVK
110 120 130 140 150
SGLRFVAPDA FHFTPRLSRL NLSFNALESL SWKTVQGLSL QELVLSGNPL
160 170 180 190 200
HCSCALRWLQ RWEEEGLGGV PEQKLQCHGQ GPLAHMPNAS CGVPTLKVQV
210 220 230 240 250
PNASVDVGDD VLLRCQVEGR GLEQAGWILT ELEQSATVMK SGGLPSLGLT
260 270 280 290 300
LANVTSDLNR KNVTCWAEND VGRAEVSVQV NVSFPASVQL HTAVEMHHWC
310 320 330 340 350
IPFSVDGQPA PSLRWLFNGS VLNETSFIFT EFLEPAANET VRHGCLRLNQ
360 370 380 390 400
PTHVNNGNYT LLAANPFGQA SASIMAAFMD NPFEFNPEDP IPVSFSPVDT
410 420 430 440 450
NSTSGDPVEK KDETPFGVSV AVGLAVFACL FLSTLLLVLN KCGRRNKFGI
460 470 480 490 500
NRPAVLAPED GLAMSLHFMT LGGSSLSPTE GKGSGLQGHI IENPQYFSDA
510 520 530 540 550
CVHHIKRRDI VLKWELGEGA FGKVFLAECH NLLPEQDKML VAVKALKEAS
560 570 580 590 600
ESARQDFQRE AELLTMLQHQ HIVRFFGVCT EGRPLLMVFE YMRHGDLNRF
610 620 630 640 650
LRSHGPDAKL LAGGEDVAPG PLGLGQLLAV ASQVAAGMVY LAGLHFVHRD
660 670 680 690 700
LATRNCLVGQ GLVVKIGDFG MSRDIYSTDY YRVGGRTMLP IRWMPPESIL
710 720 730 740 750
YRKFTTESDV WSFGVVLWEI FTYGKQPWYQ LSNTEAIDCI TQGRELERPR
760 770 780 790
ACPPEVYAIM RGCWQREPQQ RHSIKDVHAR LQALAQAPPV YLDVLG

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Applications	ELISA, WB
Dilution	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Manual
MSDS
Sample Preparation For Western Blotting.
Western Blotting Handbook.

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SKU	Supplier No.	Size	Your price	Quantity
BHA12909719	AF4390	100ul	$350		Add to Cart
BHA12909719	AF4390	200ul	$450		Add to Cart