Phospho-SHIP1 (Tyr1020)[Tyr1022] Antibody

Mfr.No.	AF2403
Alternative Names	Inositol polyphosphate 5 phosphatase of 145kDa ; 4 ; 5-trisphosphate 5-phosphatase 1 ; hp51CN ; Inositol polyphosphate 5 phosphatase 145kDa ; Inositol polyphosphate 5 phosphatase ; Inositol polyphosphate-5-phosphatase of 145 kDa ; INPP5D ; MGC104855 ; MGC142140 ; MGC142142 ; p150Ship ; Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 ; Phosphatidylinositol-3 ; SH2 containing inositol phosphatase isoform b ; SH2 domain containing inositol 5' phosphatase 1 ; SH2 domain containing inositol phosphatase 1 ; SH2 domain-containing inositol phosphatase 1 ; SH2 domain-containing inositol-5''-phosphatase 1 ; SHIP-1 ; SHIP1 ; SHIP1_HUMAN ; Signaling inositol polyphosphate 5 phosphatase SIP 145 ; SIP-145 ; SIP145 ;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Immunogen	A synthesized peptide derived from human SHIP1 around the phosphorylation site of Tyr1020.
Molecular Weight	Observed Mol.Wt.: 145kDa. Predicted Mol.Wt.: 134kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-SHIP1 (Tyr1020) Antibody detects endogenous levels of SHIP1.
Subcellular Location	Cytoplasm. Membrane. Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate to membrane localization.

Uniprot

Q92835

Gene Id

3635

Sequence

10 20 30 40 50
MVPCWNHGNI TRSKAEELLS RTGKDGSFLV RASESISRAY ALCVLYRNCV
60 70 80 90 100
YTYRILPNED DKFTVQASEG VSMRFFTKLD QLIEFYKKEN MGLVTHLQYP
110 120 130 140 150
VPLEEEDTGD DPEEDTVESV VSPPELPPRN IPLTASSCEA KEVPFSNENP
160 170 180 190 200
RATETSRPSL SETLFQRLQS MDTSGLPEEH LKAIQDYLST QLAQDSEFVK
210 220 230 240 250
TGSSSLPHLK KLTTLLCKEL YGEVIRTLPS LESLQRLFDQ QLSPGLRPRP
260 270 280 290 300
QVPGEANPIN MVSKLSQLTS LLSSIEDKVK ALLHEGPESP HRPSLIPPVT
310 320 330 340 350
FEVKAESLGI PQKMQLKVDV ESGKLIIKKS KDGSEDKFYS HKKILQLIKS
360 370 380 390 400
QKFLNKLVIL VETEKEKILR KEYVFADSKK REGFCQLLQQ MKNKHSEQPE
410 420 430 440 450
PDMITIFIGT WNMGNAPPPK KITSWFLSKG QGKTRDDSAD YIPHDIYVIG
460 470 480 490 500
TQEDPLSEKE WLEILKHSLQ EITSVTFKTV AIHTLWNIRI VVLAKPEHEN
510 520 530 540 550
RISHICTDNV KTGIANTLGN KGAVGVSFMF NGTSLGFVNS HLTSGSEKKL
560 570 580 590 600
RRNQNYMNIL RFLALGDKKL SPFNITHRFT HLFWFGDLNY RVDLPTWEAE
610 620 630 640 650
TIIQKIKQQQ YADLLSHDQL LTERREQKVF LHFEEEEITF APTYRFERLT
660 670 680 690 700
RDKYAYTKQK ATGMKYNLPS WCDRVLWKSY PLVHVVCQSY GSTSDIMTSD
710 720 730 740 750
HSPVFATFEA GVTSQFVSKN GPGTVDSQGQ IEFLRCYATL KTKSQTKFYL
760 770 780 790 800
EFHSSCLESF VKSQEGENEE GSEGELVVKF GETLPKLKPI ISDPEYLLDQ
810 820 830 840 850
HILISIKSSD SDESYGEGCI ALRLEATETQ LPIYTPLTHH GELTGHFQGE
860 870 880 890 900
IKLQTSQGKT REKLYDFVKT ERDESSGPKT LKSLTSHDPM KQWEVTSRAP
910 920 930 940 950
PCSGSSITEI INPNYMGVGP FGPPMPLHVK QTLSPDQQPT AWSYDQPPKD
960 970 980 990 1000
SPLGPCRGES PPTPPGQPPI SPKKFLPSTA NRGLPPRTQE SRPSDLGKNA
1010 1020 1030 1040 1050
GDTLPQEDLP LTKPEMFENP LYGSLSSFPK PAPRKDQESP KMPRKEPPPC
1060 1070 1080 1090 1100
PEPGILSPSI VLTKAQEADR GEGPGKQVPA PRLRSFTCSS SAEGRAAGGD
1110 1120 1130 1140 1150
KSQGKPKTPV SSQAPVPAKR PIKPSRSEIN QQTPPTPTPR PPLPVKSPAV
1160 1170 1180
LHLQHSKGRD YRDNTELPHH GKHRPEEGPP GPLGRTAMQ

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.