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Home / Antibodies

Phospho-S1PR1 (T236) Antibody

BHA10538643
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Tel
+1 866.986.9598
Email
[email protected]
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Uniprot P21453
Database Links

HGNC:3165

OMIM:601974

KEGG:hsa:1901

STRING:9606.ENSP00000305416

UniGene:Hs.154210
Function G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
Pathway FoxO signaling pathway Sphingolipid signaling pathway
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, IF, ELISA
Description WB ; IF ; ELISA, WB ; ELISA ; IF
Dilution

IF1:200-1:1000
ELISA1:10000
Tested Application WB,IF,ELISA;IF:1/200-1/1000.ELISA:1/10000
Datasheet
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10538643 CSB-PA007881 100μg $168.78
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BHA10538643 CSB-PA007881 50μg $123
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