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Home / Antibodies

Phospho-PRKCA (Y657) Antibody

BHA10539031
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
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Uniprot P17252
Database Links

HGNC:9393

OMIM:176960

KEGG:hsa:5578

STRING:9606.ENSP00000408695

UniGene:Hs.531704
Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42
Pathway Calcium signaling pathway ErbB signaling pathway HIF-1 signaling pathway MAPK signaling pathway Melanogenesis mTOR signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Wnt signaling pathway Focal adhesion Gap junction Vascular smooth muscle contraction MAPK Erk pathway Ras signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Natural killer cell mediated cytotoxicity Th17 cell differentiation Thyroid hormone synthesis AGE-RAGE signaling pathway in diabetic complications Oxidative Phosphorylation Phosphatidylinositol signaling system Phospholipase D signaling pathway Rap1 signaling pathway Sphingolipid signaling pathway Glutamatergic synapse Inflammatory Pain Inhibitors of axonal regeneration
Protein Families Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, ELISA
Description WB ; ELISA
Dilution

WB1:500-1:2000
ELISA1:10000
Tested Application WB,ELISA;WB:1/500-1/2000.ELISA:1/10000
Datasheet
Western Blotting(WB) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10539031 CSB-PA030235 100μg $168.78
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BHA10539031 CSB-PA030235 50μg $123
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