Phospho-PKM2 (Ser37) Antibody

Mfr.No.	AF7231
Alternative Names	CTHBP ; Cytosolic thyroid hormone binding protein ; Cytosolic thyroid hormone-binding protein ; KPYM_HUMAN ; MGC3932 ; OIP 3 ; OIP-3 ; OIP3 ; OPA interacting protein 3 ; Opa-interacting protein 3 ; p58 ; PK muscle type ; PK, muscle type ; PK2 ; PK3 ; PKM ; PKM2 ; pykm ; Pyruvate kinase 2/3 ; Pyruvate kinase 3 ; Pyruvate kinase isozymes M1/M2 ; Pyruvate kinase muscle ; Pyruvate kinase muscle isozyme ; pyruvate kinase PKM ; Pyruvate kinase, muscle 2 ; TCB ; THBP1 ; Thyroid hormone binding protein 1 ; Thyroid hormone binding protein cytosolic ; Thyroid hormone-binding protein 1 ; Tumor M2 PK ; Tumor M2-PK ;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Immunogen	A synthesized peptide derived from human PKM2 around the phosphorylation site of Ser37.
Molecular Weight	Observed Mol.Wt.: 60kd. Predicted Mol.Wt.: 58kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-PKM2(Ser37) Antibody detects endogenous levels of PKM2 only when phosphorylated at Ser37.
Subcellular Location	Cytoplasm. Nucleus. Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic actvity.

Uniprot

P14618

Gene Id

5315

Sequence

10 20 30 40 50
MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT
60 70 80 90 100
IGPASRSVET LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRTATESFAS
110 120 130 140 150
DPILYRPVAV ALDTKGPEIR TGLIKGSGTA EVELKKGATL KITLDNAYME
160 170 180 190 200
KCDENILWLD YKNICKVVEV GSKIYVDDGL ISLQVKQKGA DFLVTEVENG
210 220 230 240 250
GSLGSKKGVN LPGAAVDLPA VSEKDIQDLK FGVEQDVDMV FASFIRKASD
260 270 280 290 300
VHEVRKVLGE KGKNIKIISK IENHEGVRRF DEILEASDGI MVARGDLGIE
310 320 330 340 350
IPAEKVFLAQ KMMIGRCNRA GKPVICATQM LESMIKKPRP TRAEGSDVAN
360 370 380 390 400
AVLDGADCIM LSGETAKGDY PLEAVRMQHL IAREAEAAIY HLQLFEELRR
410 420 430 440 450
LAPITSDPTE ATAVGAVEAS FKCCSGAIIV LTKSGRSAHQ VARYRPRAPI
460 470 480 490 500
IAVTRNPQTA RQAHLYRGIF PVLCKDPVQE AWAEDVDLRV NFAMNVGKAR
510 520 530
GFFKKGDVVI VLTGWRPGSG FTNTMRVVPV P

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.