Phospho-JAK1 (Tyr1022/Tyr1023)[Tyr1034/Tyr1035] Antibody

Mfr.No.	AF2012
Alternative Names	JAK 1 ; JAK 1A ; JAK 1B ; JAK-1 ; JAK1 ; JAK1_HUMAN ; JAK1A ; JAK1B ; Janus kinase 1 (a protein tyrosine kinase) ; Janus kinase 1 ; JTK3 ; Tyrosine protein kinase JAK 1 ; Tyrosine protein kinase JAK1 ; Tyrosine-protein kinase JAK1 ;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain.
Immunogen	A synthesized peptide derived from human JAK1 around the phosphorylation site of Tyr1034/Tyr1035.
Molecular Weight	Observed Mol.Wt.: 130kDa. Predicted Mol.Wt.: 134kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-JAK1 (Tyr1034/Tyr1035) Antibody detects endogenous levels of JAK1 only when phosphorylated at Tyr1034/Tyr1035.
Subcellular Location	Endomembrane system. Wholly intracellular, possibly membrane associated.

Uniprot

P23458

Gene Id

3716

Sequence

10	20	30	40	50
MQYLNIKEDC	NAMAFCAKMR	SSKKTEVNLE	APEPGVEVIF	YLSDREPLRL
60	70	80	90	100
GSGEYTAEEL	CIRAAQACRI	SPLCHNLFAL	YDENTKLWYA	PNRTITVDDK
110	120	130	140	150
MSLRLHYRMR	FYFTNWHGTN	DNEQSVWRHS	PKKQKNGYEK	KKIPDATPLL
160	170	180	190	200
DASSLEYLFA	QGQYDLVKCL	APIRDPKTEQ	DGHDIENECL	GMAVLAISHY
210	220	230	240	250
AMMKKMQLPE	LPKDISYKRY	IPETLNKSIR	QRNLLTRMRI	NNVFKDFLKE
260	270	280	290	300
FNNKTICDSS	VSTHDLKVKY	LATLETLTKH	YGAEIFETSM	LLISSENEMN
310	320	330	340	350
WFHSNDGGNV	LYYEVMVTGN	LGIQWRHKPN	VVSVEKEKNK	LKRKKLENKH
360	370	380	390	400
KKDEEKNKIR	EEWNNFSYFP	EITHIVIKES	VVSINKQDNK	KMELKLSSHE
410	420	430	440	450
EALSFVSLVD	GYFRLTADAH	HYLCTDVAPP	LIVHNIQNGC	HGPICTEYAI
460	470	480	490	500
NKLRQEGSEE	GMYVLRWSCT	DFDNILMTVT	CFEKSEQVQG	AQKQFKNFQI
510	520	530	540	550
EVQKGRYSLH	GSDRSFPSLG	DLMSHLKKQI	LRTDNISFML	KRCCQPKPRE
560	570	580	590	600
ISNLLVATKK	AQEWQPVYPM	SQLSFDRILK	KDLVQGEHLG	RGTRTHIYSG
610	620	630	640	650
TLMDYKDDEG	TSEEKKIKVI	LKVLDPSHRD	ISLAFFEAAS	MMRQVSHKHI
660	670	680	690	700
VYLYGVCVRD	VENIMVEEFV	EGGPLDLFMH	RKSDVLTTPW	KFKVAKQLAS
710	720	730	740	750
ALSYLEDKDL	VHGNVCTKNL	LLAREGIDSE	CGPFIKLSDP	GIPITVLSRQ
760	770	780	790	800
ECIERIPWIA	PECVEDSKNL	SVAADKWSFG	TTLWEICYNG	EIPLKDKTLI
810	820	830	840	850
EKERFYESRC	RPVTPSCKEL	ADLMTRCMNY	DPNQRPFFRA	IMRDINKLEE
860	870	880	890	900
QNPDIVSEKK	PATEVDPTHF	EKRFLKRIRD	LGEGHFGKVE	LCRYDPEGDN
910	920	930	940	950
TGEQVAVKSL	KPESGGNHIA	DLKKEIEILR	NLYHENIVKY	KGICTEDGGN
960	970	980	990	1000
GIKLIMEFLP	SGSLKEYLPK	NKNKINLKQQ	LKYAVQICKG	MDYLGSRQYV
1010	1020	1030	1040	1050
HRDLAARNVL	VESEHQVKIG	DFGLTKAIET	DKEYYTVKDD	RDSPVFWYAP
1060	1070	1080	1090	1100
ECLMQSKFYI	ASDVWSFGVT	LHELLTYCDS	DSSPMALFLK	MIGPTHGQMT
1110	1120	1130	1140	1150
VTRLVNTLKE	GKRLPCPPNC	PDEVYQLMRK	CWEFQPSNRT	SFQNLIEGFE

ALLK

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.