Phospho-IGF1R/Insulin Receptor (Tyr1161) Antibody

Mfr.No.	AF3125
Alternative Names	CD221 ; CD221 antigen ; IGF 1 receptor ; IGF 1R ; IGF I receptor ; IGF-I receptor ; Igf1r ; IGF1R_HUMAN ; IGFIR ; IGFIRC ; IGFR ; Insulin like growth factor 1 receptor ; Insulin like growth factor 1 receptor precursor ; Insulin-like growth factor 1 receptor beta chain ; Insulin-like growth factor I receptor ; JTK13 ; MGC142170 ; MGC142172 ; MGC18216 ; Soluble IGF1R variant 1 ; Soluble IGF1R variant 2 ; CD220 ; HHF5 ; HIR B ; INSR ; Insulin receptor ; Insulin receptor subunit beta ; IR ;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	InsR a receptor tyrosine kinase that binds insulin and key mediator of the metabolic effects of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K).
Immunogen	A synthesized peptide derived from human IGF1R around the phosphorylation site of Tyrosine 1161.
Molecular Weight	Observed Mol.Wt.: 90,155kDa. Predicted Mol.Wt.: 155kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-IGF1R (Tyr1161) Antibody detects endogenous levels of IGF1R only when phosphorylated at Tyrosine 1161.
Subcellular Location	Cell membrane.

Uniprot

P08069 ; P06213

Gene Id

34803643

Sequence

10	20	30	40	50
MKSGSGGGSP	TSLWGLLFLS	AALSLWPTSG	EICGPGIDIR	NDYQQLKRLE
60	70	80	90	100
NCTVIEGYLH	ILLISKAEDY	RSYRFPKLTV	ITEYLLLFRV	AGLESLGDLF
110	120	130	140	150
PNLTVIRGWK	LFYNYALVIF	EMTNLKDIGL	YNLRNITRGA	IRIEKNADLC
160	170	180	190	200
YLSTVDWSLI	LDAVSNNYIV	GNKPPKECGD	LCPGTMEEKP	MCEKTTINNE
210	220	230	240	250
YNYRCWTTNR	CQKMCPSTCG	KRACTENNEC	CHPECLGSCS	APDNDTACVA
260	270	280	290	300
CRHYYYAGVC	VPACPPNTYR	FEGWRCVDRD	FCANILSAES	SDSEGFVIHD
310	320	330	340	350
GECMQECPSG	FIRNGSQSMY	CIPCEGPCPK	VCEEEKKTKT	IDSVTSAQML
360	370	380	390	400
QGCTIFKGNL	LINIRRGNNI	ASELENFMGL	IEVVTGYVKI	RHSHALVSLS
410	420	430	440	450
FLKNLRLILG	EEQLEGNYSF	YVLDNQNLQQ	LWDWDHRNLT	IKAGKMYFAF
460	470	480	490	500
NPKLCVSEIY	RMEEVTGTKG	RQSKGDINTR	NNGERASCES	DVLHFTSTTT
510	520	530	540	550
SKNRIIITWH	RYRPPDYRDL	ISFTVYYKEA	PFKNVTEYDG	QDACGSNSWN
560	570	580	590	600
MVDVDLPPNK	DVEPGILLHG	LKPWTQYAVY	VKAVTLTMVE	NDHIRGAKSE
610	620	630	640	650
ILYIRTNASV	PSIPLDVLSA	SNSSSQLIVK	WNPPSLPNGN	LSYYIVRWQR
660	670	680	690	700
QPQDGYLYRH	NYCSKDKIPI	RKYADGTIDI	EEVTENPKTE	VCGGEKGPCC
710	720	730	740	750
ACPKTEAEKQ	AEKEEAEYRK	VFENFLHNSI	FVPRPERKRR	DVMQVANTTM
760	770	780	790	800
SSRSRNTTAA	DTYNITDPEE	LETEYPFFES	RVDNKERTVI	SNLRPFTLYR
810	820	830	840	850
IDIHSCNHEA	EKLGCSASNF	VFARTMPAEG	ADDIPGPVTW	EPRPENSIFL
860	870	880	890	900
KWPEPENPNG	LILMYEIKYG	SQVEDQRECV	SRQEYRKYGG	AKLNRLNPGN
910	920	930	940	950
YTARIQATSL	SGNGSWTDPV	FFYVQAKTGY	ENFIHLIIAL	PVAVLLIVGG
960	970	980	990	1000
LVIMLYVFHR	KRNNSRLGNG	VLYASVNPEY	FSAADVYVPD	EWEVAREKIT
1010	1020	1030	1040	1050
MSRELGQGSF	GMVYEGVAKG	VVKDEPETRV	AIKTVNEAAS	MRERIEFLNE
1060	1070	1080	1090	1100
ASVMKEFNCH	HVVRLLGVVS	QGQPTLVIME	LMTRGDLKSY	LRSLRPEMEN
1110	1120	1130	1140	1150
NPVLAPPSLS	KMIQMAGEIA	DGMAYLNANK	FVHRDLAARN	CMVAEDFTVK
1160	1170	1180	1190	1200
IGDFGMTRDI	YETDYYRKGG	KGLLPVRWMS	PESLKDGVFT	TYSDVWSFGV
1210	1220	1230	1240	1250
VLWEIATLAE	QPYQGLSNEQ	VLRFVMEGGL	LDKPDNCPDM	LFELMRMCWQ
1260	1270	1280	1290	1300
YNPKMRPSFL	EIISSIKEEM	EPGFREVSFY	YSEENKLPEP	EELDLEPENM
1310	1320	1330	1340	1350
ESVPLDPSAS	SSSLPLPDRH	SGHKAENGPG	PGVLVLRASF	DERQPYAHMN
1360
GGRKNERALP	LPQSSTC

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.