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Home / Antibodies

Phospho-EGFR (S1071) Antibody

BHA10539624
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
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Request More Infos
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Uniprot P00533
Database Links

HGNC:3236

OMIM:131550

KEGG:hsa:1956

STRING:9606.ENSP00000275493

UniGene:Hs.488293
Function Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).
Pathway Calcium signaling pathway ErbB signaling pathway Estrogen signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway Focal adhesion Gap junction Regulation of actin cytoskeleton Adherens junction Ras signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Rap1 signaling pathway Endocytosis
Protein Families Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Tissue Specificity Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, ELISA
Description WB ; ELISA
Dilution

WB1:500-1:2000
ELISA1/5000
Tested Application WB,ELISA;WB:1/500-1/2000.ELISA:1/5000
Datasheet
Western Blotting(WB) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10539624 CSB-PA007968 100μg $168.78
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BHA10539624 CSB-PA007968 50μg $123
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