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Home / Primary Antibodies

Phospho-BCL2 (Ser87) Antibody

SKU : BHA10560106

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA971921
Alternative Names	Apoptosis regulator Bcl-2; BCL2;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).Nencioni L, et al. (2009)J Biol Chem 284, 16004-15. Pattingre S, et al. (2009)J Biol Chem 284, 2719-28. Wei Y, et al. (2008)Mol Cell 30, 678-88.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 87 (A-L-S(p)-P-V) derived from Human BCL-2.
Involvement In Disease	A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Nencioni L, et al. (2009)J Biol Chem 284, 16004-15. Pattingre S, et al. (2009)J Biol Chem 284, 2719-28. Wei Y, et al. (2008)Mol Cell 30, 678-88.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of BCL-2 only when phosphorylated at serine 87.
Subcellular Location	Mitochondrion outer membrane, Single-pass membrane protein, Nucleus membrane, Single-pass membrane protein, Endoplasmic reticulum membrane, Single-pass membrane protein

Uniprot	P10415
Gene Id	596
Database Links	HGNC:990 OMIM:151430 KEGG:hsa:596 STRING:9606.ENSP00000329623 UniGene:Hs.150749
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release
Pathway	Estrogen signaling pathway Hedgehog signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway PI3K-Akt signaling pathway Focal adhesion NF-kappa B signaling pathway Apoptosis Autophagy Necroptosis Protein processing in endoplasmic reticulum NOD-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications ER Stress pathway Neurotrophin signaling pathway
Protein Families	Bcl-2 family
Tissue Specificity	Expressed in a variety of tissues.
Weight	22,337 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560106	CSB-PA971921	100ul	$360		Add to Cart

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