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Home / Primary Antibodies / Polyclonal Antibodies

PDCD6 antibody

SKU : BHA10806234

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Mfr.No.	FNab06242
Alternative Names	ALG2
Background	This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.
Host	Rabbit
Immunogen	programmed cell death 6
Isotype	IgG
Molecular Weight	16 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ALG2

Uniprot	O75340
Gene Id	10016
Research Area	Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:200 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab06242.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806234	FNab06242	100ug	$240		Add to Cart

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