Proprotein convertase subtilysin/Kexin Type4 (PCSK4) is a protein convertase enzymes in spermatozoa acrosome membrane, it has an important role in the acrosome reaction through endoproteolytic process that converts the precursor proteins into bioactive protein as a necessary substance to penetrate on the zona pellucida (PMID: 16040806 ). The molecular mass of pro-PCSK4 is 72kDa, and mature PCSK4 is 54 kDa (PMID: 16040806, 19109312).
Clonality
polyclonal
Host
Rabbit
Immunogen
proprotein convertase subtilisin/kexin type 4
Immunogen Region
endomucin
Isotype
IgG
Molecular Weight
26 kDa, 72 kDa
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500-1:2000
Synonyms
PC4, PCSK4, Proprotein convertase 4, SPC5
Uniprot
Q6UW60
Gene Id
54760
Research Area
Signal Transduction, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:20-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10350.pdf" target="_blank">Data Sheet</ a>