Rabbit Anti-Human p90 RSK1 Polyclonal

Mfr.No.	SPC-147, SPC-147F, SPC-147F-A390, SPC-147F-A488, SPC-147F-A594, SPC-147F-BI, SPC-147F-FITC
Immunogen Species	Human
Alternative Names	p90RSK Antibody, RSK1 Antibody, RPS6KA1 Antibody, p90 RSK1 Antibody, MAPKAPK-1a Antibody, p90S6K Antibody, Ribosomal S6 kinase 1 Antibody, RSK1 Antibody, MAP kinase-activated protein kinase 1a Antibody, MAPK-activated protein kinase 1a Antibody, EC:2.7.11.1 Antibody, p90-RSK 1 Antibody, Ribosomal protein S6 kinase alpha-1 Antibody, S6K-alpha-1 Antibody, p90RSK1 Antibody, 90 kDa ribosomal protein S6 kinase 1 Antibody, RSK-1 Antibody, MAPKAP kinase 1a Antibody, MAPKAPK1A Antibody
Categories	Antibodies
Cellular Localization	Cytoplasm, Nucleus
Certificate Of Analysis	0.25 mg/ml was sufficient for detection of SPC-147 in lysates prepared from mouse brain, spleen and intestine.
Clonality	Polyclonal
Description	Rabbit Anti-Human p90 RSK1 Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Human p90 RSK1 C-terminal peptide, conjugated to KLH, Homo Sapiens (Human)
Immunogen Region	Human p90 RSK1 C-terminal peptide, conjugated to KLH
Launch Date	2007/06/01
Net Weight (g)	0.4
Reactivity	Rat, Mouse, Human, Bovine
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Bovine, Human

Swissprot	Q15418
Accession Number	NP_002944.2
Gene Id	6195
Target	RSK1
Research Area	Cell Signaling, Post-translational Modifications, Phosphorylation

Buffer	PBS, 50% glycerol, 0.01% sodium azide
Concentration	0.25 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:50); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Scientific Background	The p90 ribosomal S6 kinase (Rsk) family comprises four mammalian serine/threonine kinases (Rsk14). In the past, S6K1 and S6K2 were thought to be the predominant operating S6 kinases, however RSK 1 and 2 have been shown to phosphorylate S6 in response to the ERK pathway, or otherwise known as the extra cellular signal-regulated kinases pathway. RSK 1 in particular is very multifunctional as it participates in nuclear signaling, regulates nuclear factors, regulates several transcription factors like c-Fos, and interacts with the transcriptional coactivator CREB-binding protein. As a result, RSK1 seems to have an important role in cellular growth control and proliferation. (1-5).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~90kDa.
Storage	-20ºC
Storage Buffer	PBS, 50% glycerol, 0.01% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ELISA, IP, WB, ICC/IF
Description	WB ; ICC ; IF ; IP ; ELISA
Dilution	WB (1:1000), ICC/IF (1:50); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Roux, P. (2007). UCSD-Nature Molecule Pages. 2. Fro¨din, M. and Gammeltoft, S. (1999) Mol. Cell. Endocrinol. 151: 65-77. 3. Merienne, K. et al. (1998) J. Med. Genet. 35: 890-894. 4. De Cesare, D. et al. (1998) Proc. Natl. Acad. Sci. 95: 12202-12207. 5. Joel, P. B. et al. (1998) Mol. Cell. Biol. 18: 1978-1984.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11906737-1	SPC-147F	Unconjugated	400 ul	$202	Add to Cart
BHA11906737-2	SPC-147F-A390	ATTO 390	400 ul	$256	Add to Cart
BHA11906737-3	SPC-147F-A488	ATTO 488	400 ul	$255	Add to Cart
BHA11906737-4	SPC-147F-A594	ATTO 594	400 ul	$255	Add to Cart
BHA11906737-5	SPC-147F-BI	Biotin	400 ul	$250	Add to Cart
BHA11906737-6	SPC-147F-FITC	FITC	400 ul	$245	Add to Cart

p90 RSK1 Antibody - SPC-147