Rabbit Anti-Human p53 Polyclona

Mfr.No.	SPC-682, SPC-682D, SPC-682D-A390, SPC-682D-A488, SPC-682D-A594, SPC-682D-ALP, SPC-682D-APC, SPC-682D-BI, SPC-682D-FITC, SPC-682D-HRP, SPC-682D-PCP, SPC-682D-RPE, SPC-682S
Immunogen Species	Human
Alternative Names	TP53 Antibody, Tumor Protein 53 Antibody, BCC7 Antibody, LFS1 Antibody, TRP53 Antibody, p53 tumor suppressor Antibody
Categories	Antibodies
Cellular Localization	Endoplasmic Reticulum, Mitochondrion matrix, Cytoplasm, Nucleus, PML body
Certificate Of Analysis	A 1:1000 dilution of SPC-682 was sufficient for detection of p53 on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human p53 Polyclona
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide from the C-terminal of human tumor protein p53., Homo Sapiens (Human)
Immunogen Region	Synthetic peptide from the C-terminal of human tumor protein p53.
Launch Date	2015/10/01
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human

Swissprot	P04637
Accession Number	NP_000537.3
Gene Id	7157
Target	p53
Research Area	Cancer, Cell Cycle, p53 Pathway, Tumor suppressors, Apoptosis, Cell Signaling, Epigenetics and Nuclear Signaling, DNA/RNA, DNA Damage and Repair

Buffer	PBS, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Scientific Background	The p53 protein (tumor protein 53 or TP53) is a DNA-binding cell cycle-regulating transcription factor that governs cell division and the fine balance between cell death and cell survival (1). P53 plays a critical role in tumor suppression and hence it is often described as "the guardian of the genome", "the guardian angel gene", or the "master watchman." This also refers to its role in conserving stability by preventing genome mutation (2). Defects in p53 are linked to >50% of human cancers, and restoring p53 function to these cancer cells can induce growth arrest and apoptosis (3). When p53 has been damaged, it can also lead to autoimmune disorders (4, 5).
Shipping Temperature	Blue Ice or 4°C
Specificity	Predicted molecular weight at ~43.7kDa. Observed bands at ~53kDa.
Storage	-20ºC
Storage Buffer	PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, ICC/IF
Description	WB ; ICC ; IF
Dilution	WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Georescu C.V., Saftoiu A., Georgescu C.C., Ciurea R. and Ciurea T. (2007) J Gastrointestin Liver Dis. 16(2): 133-9. 2. Strachan T., et al. (1999) Human Molecular Genetics 2. Ch. 18: Cancer Genetics. 3. Hansen J.E., et al. (2007) Cancer Research 67: 1769-1774. 4. Di Cesare E., et al. (2001) Ann Clin Lab Sci 31: 253-8. 5. Akere A., Otegbayo J.A. (2007) Singapore Med J. 48(1): 41-4.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11908983-1	SPC-682D	Unconjugated	100 ug	$331	Add to Cart
BHA11908983-2	SPC-682D-A390	ATTO 390	100 ug	$385	Add to Cart
BHA11908983-3	SPC-682D-A488	ATTO 488	100 ug	$384	Add to Cart
BHA11908983-4	SPC-682D-A594	ATTO 594	100 ug	$384	Add to Cart
BHA11908983-5	SPC-682D-ALP	Alkaline Phosphatase	100 ug	$377	Add to Cart
BHA11908983-6	SPC-682D-APC	APC	100 ug	$383	Add to Cart
BHA11908983-7	SPC-682D-BI	Biotin	100 ug	$380	Add to Cart
BHA11908983-8	SPC-682D-FITC	FITC	100 ug	$375	Add to Cart
BHA11908983-9	SPC-682D-HRP	HRP	100 ug	$371	Add to Cart
BHA11908983-10	SPC-682D-PCP	PerCP	100 ug	$383	Add to Cart
BHA11908983-11	SPC-682D-RPE	RPE	100 ug	$381	Add to Cart
BHA11908983-12	SPC-682S	Unconjugated	12 ug	$44	Add to Cart

p53 Antibody - SPC-682