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Home / Primary Antibodies / Monoclonal Antibodies

p38 alpha (MAP Kinase) Antibody, Clone 9F12 - SMC-152

BHA11900740
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+1 866.986.9598
Email
[email protected]
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Swissprot Q16539
Accession Number NP_001306.1
Gene Id 1432
Target p38 MAPK
Clone No 9F12
Research Area Cell Signaling, Post-translational Modifications, Phosphorylation, Cancer
Buffer PBS, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2alpha translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~38kDa.
Storage -20ºC
Storage Buffer PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, ELISA, IHC, IP, WB
Description WB ; IHC ; IP ; ELISA ; AM
Dilution WB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Pearson, G. et al (2001). Endocrine Reviews 22 (2): 153-183.

2. Fan, Y. et al (2007) Mol. Cells 23 (1): 30-38.

3. Han, J. et al. (1994) Science 265: 808-811.

4. Van, L. A., et al. (2004) Faseb J. 18: 1946?1948.

5. Deng et al. (2003) Cell. 115: 61-70.

6. Salojin KV, et al. (2006) J Immunol. 176 (3):1899-907.

7. Medicherla S. et al. (2006). J Pharmacol Exp Ther.318(1): 99-107.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11900740-1 SMC-152D Unconjugated 100 ug $266
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BHA11900740-2 SMC-152C Unconjugated 25 ug $125
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BHA11900740-3 SMC-152D-A390 ATTO 390 100 ug $320
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BHA11900740-4 SMC-152D-A488 ATTO 488 100 ug $319
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BHA11900740-5 SMC-152D-A594 ATTO 594 100 ug $319
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BHA11900740-6 SMC-152D-ALP Alkaline Phosphatase 100 ug $312
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BHA11900740-7 SMC-152D-APC APC 100 ug $318
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BHA11900740-8 SMC-152D-BI Biotin 100 ug $315
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BHA11900740-9 SMC-152D-FITC FITC 100 ug $310
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BHA11900740-10 SMC-152D-HRP HRP 100 ug $305
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BHA11900740-11 SMC-152D-PCP PerCP 100 ug $318
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BHA11900740-12 SMC-152D-RPE RPE 100 ug $316
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BHA11900740-13 SMC-152S Unconjugated 12 ug $44
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