Rabbit Anti-Human p33 ING1 Polyclonal

Mfr.No.	SPC-145, SPC-145F, SPC-145F-A390, SPC-145F-A488, SPC-145F-A594, SPC-145F-BI, SPC-145F-FITC
Immunogen Species	Mouse
Alternative Names	Growth inhibitor ING1 Antibody, ING1 Antibody, inhibitor of growth 1 Antibody, p24ING1c Antibody, p33 Antibody, p33ING Antibody, p33ING1b Antibody, p33ING1c Antibody, p47 Antibody, p47ING1a Antibody, tumor suppressor ING1 Antibody
Categories	Antibodies
Cellular Localization	Nucleus
Certificate Of Analysis	0.25 mg/ml was sufficient for detection of SPC-145 in lysates prepared from human melanoma cell lines by western blot analysis.
Clonality	Polyclonal
Description	Rabbit Anti-Human p33 ING1 Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Mouse p33 ING1 N-terminal peptide –KLH conjugates, Homo Sapiens (Human)
Immunogen Region	Mouse p33 ING1 N-terminal peptide KLH conjugates
Launch Date	2011/01/01
Net Weight (g)	0.4
Reactivity	Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Human

Swissprot	Q9QXV3
Accession Number	NP_036049.2
Gene Id	26356
Target	ING1
Research Area	Cell Signaling, Epigenetics and Nuclear Signaling, Cancer

Buffer	TBS, 50% glycerol, 0.01% sodium azide
Concentration	0.25 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:50); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Scientific Background	The p33ING1 protein encodes a 33-kD, 294-amino acid protein that displays the characteristics of a tumor suppressor gene. The p33ING1 protein is a regulator of cell cycle, senescence, and apoptosis. It can mediate growth arrest, anchor dependent growth and influence chemo sensitivity (1-4). It also has a proposed role as a growth regulator, which is consistent with its location in the nucleus (5). It has been demonstrated that the ING1 gene has three exons and that four mRNA variants are transcribed from three different promoter regions (p33 ING1, p24 ING1, p27 ING1, p47 IG1) (6, 7). ING1 can possibly influence the above biological functions depending on which variant is expressed (1-4).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~33kDa.
Storage	-20ºC
Storage Buffer	TBS, 50% glycerol, 0.01% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ELISA, WB, ICC/IF
Description	WB ; ICC ; IF ; ELISA
Dilution	WB (1:1000), ICC/IF (1:50); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Cheung, K.J., Jr. and Li, G. (2002) Int. J. Oncol. 21(6): 1361-1365. 2. Cheung, K.J., Jr. and Li, G. (2002) Exp. Cell Res. 279(2): 291-28. 3. Cheung, K.J., Jr. and Li, G. (2002) Int. J. Oncol. 20(6):1319-1322. 4. Cheung, K.J., Jr. and Li, G. (2001) Exp. Cell Res. 268(1): 1-6. 5. Garkavtsev, I. et al. (1996). Nat Genet. 14(4): 415-420. 6. Gunduz, M. et al. (2000). Cancer Res. 60(12): 3143-6. 7. Jager, D. et al. (1999). Cancer Res. 59: 6197-6204.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11906701-1	SPC-145F	Unconjugated	400 ul	$318	Add to Cart
BHA11906701-2	SPC-145F-A390	ATTO 390	400 ul	$372	Add to Cart
BHA11906701-3	SPC-145F-A488	ATTO 488	400 ul	$371	Add to Cart
BHA11906701-4	SPC-145F-A594	ATTO 594	400 ul	$371	Add to Cart
BHA11906701-5	SPC-145F-BI	Biotin	400 ul	$366	Add to Cart
BHA11906701-6	SPC-145F-FITC	FITC	400 ul	$361	Add to Cart

p33 ING1 Antibody - SPC-145