High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth factor receptor; TRK; TRK1 transforming tyrosine kinase protein
Antigen
NTRK1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17210-5.Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12270-5Inoue K, et al. J Biol Chem. 2007 Aug 17;282(33):24175-84
Host
Rabbit
Immunogen
Peptide sequence around aa.789~793 (P-V-Y-L-D) derived from Human TrkA.
Involvement In Disease
Congenital insensitivity to pain with anhidrosis (CIPA)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17210-5. Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12270-5 Inoue K, et al. J Biol Chem. 2007 Aug 17;282(33):24175-84
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total TrkA protein.
Subcellular Location
Cell membrane, Single-pass type I membrane protein, Early endosome membrane, Single-pass type I membrane protein, Late endosome membrane, Single-pass type I membrane protein
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand
Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Tissue Specificity
Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.