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Home / Primary Antibodies / Polyclonal Antibodies

NR5A1 antibody

SKU : BHA10805839

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Mfr.No.	FNab05847
Alternative Names	AD4BP ; FTZF1 ; SF1
Background	Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine(By similarity). Binds phospholipids with a phosphatidylinositol(PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Host	Rabbit
Immunogen	nuclear receptor subfamily 5, group A, member 1
Isotype	IgG
Molecular Weight	53 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	AD4BP, FTZF1, SF1

Uniprot	Q13285
Gene Id	2516
Research Area	Developmental biology, Immunology, Signal Transduction, Metabolism
Weight	52kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:500-1:5000
IP	1:200-1:1000
IHC	1:20-1:200

Tested Application

WB: 1:500-1:5000; IP: 1:200-1:1000; IHC: 1:20-1:200

Manual	FNab05847.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805839	FNab05847	100ug	$240		Add to Cart

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