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Home / Primary Antibodies / Monoclonal Antibodies

Nitrotyrosine Antibody, Clone 39B6 - SMC-154

BHA11900780
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+1 866.986.9598
Email
[email protected]
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Target Nitrotyrosine
Clone No 39B6
Research Area Cancer, Oxidative Stress, Cell Signaling, Post-translational Modifications, Nitration, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Neuroscience
Buffer PBS, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1400), IHC (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling (2). While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosino-philperoxidase (3), myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase.
Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury (1). The presence of nitro tyrosine-containing proteins therefore has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (4).
Shipping Temperature Blue Ice or 4°C
Specificity Recognizes 3-nitrotyrosine moieties. No detectable cross-reactivity with non-nitrated tyrosine. Not species specific.
Storage -20ºC
Storage Buffer PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Trademark MOLECULAR SIGNATURE
Applications AM, ELISA, IHC, IP, WB, ICC/IF, FCM
Description WB ; IHC ; ICC ; IF ; IP ; ELISA ; FCM ; AM
Dilution WB (1:1400), IHC (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Girault I. et al. (2001). Free Radical Biology and Medicine, 31 (11): 1375-1387.

2. Gow AJ, Farkouh CR, Munson DA, Posencheq MA, and Ischiropoulos H. (2004). Am J Physiol Lung Cell Mol Physiol. 287(2): L262-8.

3. Takemoto K. et al (2007). Acta Med Okayama 61(1): 17-30.

4. Reynolds MR. et al. (2006) J Nerosci. 26(42): 10636-45.

5. Pfister H., et al. (2002) Vet Pathol. 39: 190-199.

6. Khan J. et al. (1998) Biochem J. 330(2): 795-801.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11900780-1 SMC-154D Unconjugated 100 ug $343
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BHA11900780-2 SMC-154C Unconjugated 25 ug $167
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BHA11900780-3 SMC-154D-A390 ATTO 390 100 ug $397
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BHA11900780-4 SMC-154D-A488 ATTO 488 100 ug $396
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BHA11900780-5 SMC-154D-A594 ATTO 594 100 ug $396
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BHA11900780-6 SMC-154D-ALP Alkaline Phosphatase 100 ug $389
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BHA11900780-7 SMC-154D-APC APC 100 ug $395
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BHA11900780-8 SMC-154D-BI Biotin 100 ug $392
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BHA11900780-9 SMC-154D-FITC FITC 100 ug $387
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BHA11900780-10 SMC-154D-HRP HRP 100 ug $383
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BHA11900780-11 SMC-154D-PCP PerCP 100 ug $395
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BHA11900780-12 SMC-154D-RPE RPE 100 ug $393
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BHA11900780-13 SMC-154S Unconjugated 12 ug $44
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