I-kappa-B-alpha; IkappaBalpha; IKBA; MAD3; Major histocompatibility complex enhancer-binding protein MAD3
Categories
Primary Antibodies
Clonality
polyclonal
Description
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.Mattioli I, et al. (2004)J Immunol; 172(10): 6336-44.Courtois G, et al. (2003)J Clin Invest; 112(7): 1108-15.Nair A, et al. (2003) Oncogene; 22(1): 50-8.Fan C, et al. (2002)J Cell Sci; 115(Pt 24): 4843-53.Schubert SY, et al. (2002)FASEB J; 16(14): 193
Host
Rabbit
Immunogen
Synthesized non-phosphopeptide derived from Human IκB-α around the phosphorylation site of Serine 32/36.
Involvement In Disease
Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency autosomal dominant (ADEDAID)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Mattioli I, et al. (2004)J Immunol; 172(10): 6336-44. Courtois G, et al. (2003)J Clin Invest; 112(7): 1108-15. Nair A, et al. (2003) Oncogene; 22(1): 50-8. Fan C, et al. (2002)J Cell Sci; 115(Pt 24): 4843-53. Schubert SY, et al. (2002)FASEB J; 16(14): 193
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total IκB-α protein.
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.