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Home / Primary Antibodies / Polyclonal Antibodies

NEIL1 antibody

SKU : BHA10810576

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Mfr.No.	FNab10789
Background	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine(Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP(apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'-and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine(5hmC), suggesting that it acts as a specific reader of 5hmC.
Clonality	polyclonal
Host	Rabbit
Immunogen	nei endonuclease VIII-like 1(E. coli)
Immunogen Region	nei endonuclease VIII-like 1(E. coli)
Isotype	IgG
Molecular Weight	44kd
Reactivity	Human, Rat
Recommended Dilution	WB: 1:500-1:1000
Synonyms	DNA glycosylase/AP lyase Neil1, Endonuclease 8 like 1, Endonuclease VIII like 1, FPG1, hFPG1, NEH1, Nei homolog 1, Nei like protein 1, NEI1, NEIL1

Uniprot	Q96FI4
Gene Id	79661
Research Area	Metabolism

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:1000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10789.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810576	FNab10789	100ug	$240		Add to Cart

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