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Home / Primary Antibodies / Polyclonal Antibodies

NDE1 antibody

SKU : BHA10805592

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Mfr.No.	FNab05600
Alternative Names	NUDE
Background	This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.
Host	Rabbit
Immunogen	nudE nuclear distribution gene E homolog 1 (A. nidulans)
Isotype	IgG
Molecular Weight	39 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	NUDE

Uniprot	Q9NXR1
Gene Id	54820
Research Area	Developmental biology, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, IP
Description	ELISA ; WB ; IHC ; IF ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab05600.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805592	FNab05600	100ug	$240		Add to Cart

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