Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist-and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids(GR and ERs), retinoids(RARs and RXRs), thyroid hormone(TRs), vitamin D3(VDR) and prostanoids(PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Host
Rabbit
Immunogen
nuclear receptor coactivator 6
Isotype
IgG
Molecular Weight
68 kDa ; 219 kDa ; 110 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
AIB3, KIAA0181, RAP250, TRBP
Uniprot
Q14686
Gene Id
23054
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)