Condensin complex subunit 2; Non-SMC condensin I complex subunit H; Barren homolog protein 1; Chromosome-associated protein H; hCAP-H
Antigen
NCAPH
Categories
Primary Antibodies
Clonality
polyclonal
Description
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.Nomura N., DNA Res. 1:223-229(1994).The MGC Project Team; Genome Res. 14:2121-2127(2004).Cabello O.A., Mol. Biol. Cell 12:3527-3537(2001).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human NCAPH.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Nomura N., DNA Res. 1:223-229(1994). The MGC Project Team; Genome Res. 14:2121-2127(2004). Cabello O.A., Mol. Biol. Cell 12:3527-3537(2001).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total NCAPH protein.
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Protein Families
CND2 (condensin subunit 2) family
Tissue Specificity
Widely expressed at low level. Expressed in proliferating cells.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.