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Home / Primary Antibodies / Polyclonal Antibodies

NAT10 antibody

SKU : BHA10805554

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Mfr.No.	FNab05562
Alternative Names	ALP ; KIAA1709
Background	RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs(PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine(ac4C) at positions 1337 and 1842 in 18S rRNA(By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis(PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs(By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation(PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division(PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003).
Categories	Primary Antibodies
Clonality	polyclonal
Description	RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003).
Host	Rabbit
Immunogen	N-acetyltransferase 10(GCN5-related)
Isotype	IgG
Molecular Weight	116 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ALP, KIAA1709

Uniprot	Q9H0A0
Gene Id	55226
Research Area	Cell Division and Proliferation, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IP
Description	ELISA ; WB ; IF ; IP
Tested Application	WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805554	FNab05562	100ug	$240		Add to Cart

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