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Home / Primary Antibodies / Polyclonal Antibodies

MUC1 antibody

SKU : BHA10805420

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Mfr.No.	FNab05428
Alternative Names	PUM
Background	MUC1 is a type I transmembrane glycoprotein expressed by various epithelial cells of female reproductive tract, lung, breast, kidney, stomach, and pancreas. MUC1 is transcribed as a large precursor gene product, and upon translation, is cleaved in the endoplasmic reticulum, yielding two subunits: the large extracellular N-terminal subunit (MUC1-N, about 120-200 kDa) and the small cytoplasmic C-terminal subunit (MUC1-C, about 23-30 kDa).
Categories	Primary Antibodies
Clonality	polyclonal
Description	The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein- protein interactions. Modulates signaling in ERK, SRC and NF- kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Host	Rabbit
Immunogen	mucin 1, cell surface associated
Isotype	IgG
Molecular Weight	23-30 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	CA15 3, CA153, CA15-3, Carcinoma associated mucin, CD227, EMA, Episialin, H23AG, KL-6, MAM6, MUC 1, MUC1, MUC1 beta, MUC1 CT, MUC1 NT, Mucin 1, Peanut reactive urinary mucin, PEM, PEMT, Polymorphic epithelial mucin, PUM, Tumor associated mucin

Uniprot	P15941
Gene Id	4582
Research Area	Cancer, Immunology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, FC, IHC, WB
Description	ELISA ; FC ; IHC ; WB
Tested Application	WB: 1:500-1:1000; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805420	FNab05428	100ug	$280		Add to Cart

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