Rabbit Anti-Human mTOR Polyclonal

Mfr.No.	SPC-1176, SPC-1176D, SPC-1176D-A390, SPC-1176D-A488, SPC-1176D-A594, SPC-1176D-BI, SPC-1176D-FITC
Immunogen Species	Human
Alternative Names	FK506 binding protein 12 rapamycin associated protein 1 antibody, FK506 binding protein 12 rapamycin associated protein 2 antibody, FKBP rapamycin associated protein antibody, FKBP12 rapamycin complex associated protein antibody, FRAP antibody, FRAP1 antibody, FRAP2 antibody, Mammalian target of rapamycin antibody, Mechanistic target of rapamycin antibody, mTOR antibody, MTOR_HUMAN antibody, RAFT1 antibody, Rapamycin and FKBP12 target 1 antibody, Rapamycin target protein 1 antibody, Rapamycin target protein antibody, RAPT1 antibody, Serine/threonine-protein kinase mTOR antibody
Antigen	mTOR
Categories	Antibodies
Cellular Localization	Endoplasmic Reticulum Membrane, Golgi apparatus membrane, Lysosome, Cytoplasm
Certificate Of Analysis	A 1:250 dilution of SPC-1176 was sufficient for detection of mTOR in 10 ug of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Conjugate	Unconjugated, ATTO 390, ATTO 488, ATTO 594, Biotin, FITC
Description	Rabbit Anti-Human mTOR Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide of human mTOR (AA2492-2505), Homo Sapiens (Human)
Immunogen Region	Synthetic peptide of human mTOR (AA2492-2505)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human
Tissue Specificity	Expressed in numerous tissues, with highest levels in testis.

Swissprot	P42345
Accession Number	NP_004949
Gene Id	2475
Target	mTOR
Research Area	Cancer, Cell Cycle, Cell Cycle Inhibitors, Cell Signaling, Epigenetics and Nuclear Signaling, DNA/RNA, DNA Damage and Repair, DNA Damage Recognition

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Expressed in numerous tissues, with highest levels in testis.
Scientific Background	MTOR is a protein-serine/threonine kinase. It regulates various cellular pathways such as insulin signalling, eIF4e and p70S6 kinase activation for protein synthesis, HIFa, VEGF, cell proliferation, nutrient and hormone signals, ribosome biogenesis, regulation of cell cycle progrssion, angiogensis, cell polarity and cytokeleton reorganization. Dysregulation in signalling that leads to constant activation of mTOR lead to uncontrolled prolifertaion and cell cycle progression and oncogensis. Increased invasiveness has also be shown do be associated with mTOR activity. While it features a wide range of mutations, this might reflect the very large size of the protein rather than its identification as a tumour suppressor protein.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 288.892 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11915966-1	SPC-1176D	Unconjugated	100 ul	$331	Add to Cart
BHA11915966-2	SPC-1176D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11915966-3	SPC-1176D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11915966-4	SPC-1176D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11915966-5	SPC-1176D-BI	Biotin	100 ul	$380	Add to Cart
BHA11915966-6	SPC-1176D-FITC	FITC	100 ul	$375	Add to Cart

mTOR Antibody - SPC-1176

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