The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, have been implicated as important signaling intermediates in response to a broad range of ligand-activated receptor tyrosine kinases. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. A related S6 kinase, p70 S6 kinase, functions to phosphorylate the S6 protein on ribosomal 40S subunits. p70 S6 kinase b shares high sequence homology with p70 S6 kinase, except in the carboxy terminus where it contains a proline-rich domain that may be involved in SH3 domain containing protein interactions. MSK1 (also designated RLPK) is related to Rsk and p70 S6 kinase family members and is thought to be structurally similar to Rsk family members, but it may be regulated by distinct mechanisms.
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
Recombinant full-length human RPS6KA5 protein was used as the immunogen for the RPS6KA5 antibody.
Isotype
Mouse IgG2b
Species Reactivity
Human
Note
Optimal dilution of the RPS6KA5 antibody should be determined by the researcher.
Uniprot
O75582
Format
Purified
Purity
Protein A/G affinity
Storage
Aliquot the RPS6KA5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.