Mouse Anti-Rat MMP9 Monoclonal IgG2a

Mfr.No.	SMC-396, SMC-396D, SMC-396D-A390, SMC-396D-A488, SMC-396D-A594, SMC-396D-ALP, SMC-396D-APC, SMC-396D-BI, SMC-396D-FITC, SMC-396D-HRP, SMC-396D-PCP, SMC-396D-RPE, SMC-396S
Immunogen Species	Rat
Alternative Names	MMP-9 Antibody, CLG4B Antibody, 82kDa matrix metalloproteinase-9 Antibody, collagenease type 4 beta Antibody, GELB Antibody, Macrophage gelatinase Antibody, MANDP2 Antibody, Type V collagenase Antibody, 92 kDa gelatinase Antibody, 92 kDa type IV collagenase Antibody, Gelatinase B Antibody, MMP9 Antibody, Matrix metalloproteinase 9 Antibody
Categories	Antibodies
Cellular Localization	Extracellular Matrix
Certificate Of Analysis	1 ug/ml of SMC-396 was sufficient for detection of MMP9 in 20 ug of COS-1 cells (lysate) transfected with human MMP9 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Rat MMP9 Monoclonal IgG2a
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 1-708 (full length) of rat MMP9, Rattus Norvegicus (Rat)
Immunogen Region	Fusion protein amino acids 1-708 (full length) of rat MMP9
Isotype	IgG2a
Launch Date	2012/05/16
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Rattus Norvegicus (Rat)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	P50282
Accession Number	NP_112317.1
Gene Id	81687
Target	MMP9
Clone No	S51-82
Research Area	Cardiovascular System, Angiogenesis, Cardiovascular Growth Factors, Adhesion / Extracellular Matrix, Matrix Metalloproteinases, Cell Signaling, Extracellular Matrix (ECM), Enzymes, Cancer, Tumor Biomarkers, Tumor Biomarker Enzymes, Invasion/microenvironment

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	MMP9, otherwise known as matrix metalloproteinase 9, is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction and tissue remodeling, as well as in disease processes like arthritis and metastasis (1). Among the family members, MMP-2, MMP-3, MMP-7 and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis (2-4). MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein (5).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detecs ~92kDa and ~82kDa (pro and active forms).
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, IP, WB, ICC/IF, FCM
Description	WB ; IHC ; ICC ; IF ; IP ; FCM
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Hirose Y., et al. (2008) Am J Hum Genet. 82(5): 1122-1129. 2. Coussens L.M., et al. (2002) Science 295: 2387-2391. 3. Sternlicht M.D., et al. (1999) Cell 98: 137-146. 4. Vu T.H., et al. (1998) Cell 93: 411-422. 5. Nagase H., et al. (1990) Biochemistry 29: 5783-5789.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11903431-1	SMC-396D	Unconjugated	100 ug	$330	Add to Cart
BHA11903431-2	SMC-396D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11903431-3	SMC-396D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11903431-4	SMC-396D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11903431-5	SMC-396D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11903431-6	SMC-396D-APC	APC	100 ug	$382	Add to Cart
BHA11903431-7	SMC-396D-BI	Biotin	100 ug	$378	Add to Cart
BHA11903431-8	SMC-396D-FITC	FITC	100 ug	$374	Add to Cart
BHA11903431-9	SMC-396D-HRP	HRP	100 ug	$370	Add to Cart
BHA11903431-10	SMC-396D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11903431-11	SMC-396D-RPE	RPE	100 ug	$380	Add to Cart
BHA11903431-12	SMC-396S	Unconjugated	12 ug	$44	Add to Cart

MMP9 Antibody, Clone S51-82 - SMC-396