Involved in the cellular defense against the biological effects of O6-methylguanine(O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Clonality
polyclonal
Host
Rabbit
Immunogen
O-6-methylguanine-DNA methyltransferase
Immunogen Region
O-6-methylguanine-DNA methyltransferase
Isotype
IgG
Molecular Weight
22 kDa
Reactivity
Human
Recommended Dilution
IHC: 1:50 - 1:500
Synonyms
MGMT
Uniprot
P16455
Gene Id
4255
Research Area
Cancer, Immunology, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
IHC: 1:50 - 1:500
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10100.pdf" target="_blank">Data Sheet</ a>