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Home / Primary Antibodies / Polyclonal Antibodies

MAP3K3 antibody

SKU : BHA10809774

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Mfr.No.	FNab09784
Background	The mitogen-activated protein/ERK kinase kinase 3(MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.(PMID: 18206350).Cerebral cavernous malformations(CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.
Clonality	polyclonal
Host	Rabbit
Immunogen	mitogen-activated protein kinase kinase kinase 3
Immunogen Region	mitogen-actIVated protein kinase kinase kinase 3
Isotype	IgG
Molecular Weight	74 kDa
Reactivity	Human
Recommended Dilution	WB: 1:200-1:2000; IHC: 1:50-1:500
Synonyms	MAP3K3, MAPK/ERK kinase kinase 3, MAPKKK3, MEK kinase 3, MEKK 3, MEKK3

Uniprot	Q99759
Gene Id	4215
Research Area	Signal Transduction, Immunology

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:200-1:2000; IHC: 1:50-1:500

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09784.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809774	FNab09784	100ug	$260		Add to Cart

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