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Home / Antibodies

MAP2K1 Antibody

BHA10543312
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
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Uniprot Q02750
Database Links

HGNC:6840

OMIM:176872

KEGG:hsa:5604

STRING:9606.ENSP00000302486

UniGene:Hs.145442
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Pathway cAMP signaling pathway Chemokine signaling pathway ErbB signaling pathway Estrogen signaling pathway HIF-1 signaling pathway MAPK signaling pathway Melanogenesis mTOR signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Focal adhesion Gap junction Regulation of actin cytoskeleton TNF signaling pathway Vascular smooth muscle contraction Apoptosis Autophagy Cellular senescence MAPK Erk pathway Ras signaling pathway Signaling pathways regulating pluripotency of stem cells B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Natural killer cell mediated cytotoxicity Osteoclast differentiation T cell receptor signaling pathway Toll-like receptor signaling pathway Apelin signaling pathway cGMP-PKG signaling pathway FoxO signaling pathway Insulin signaling pathway Oxidative Phosphorylation Phospholipase D signaling pathway Rap1 signaling pathway Sphingolipid signaling pathway Excitatory synapse pathway Neurotrophin signaling pathway
Protein Families Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
Tissue Specificity Widely expressed, with extremely low levels in brain.
Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Applications WB, ELISA
Description WB ; ELISA
Dilution

WB1:500-10000
ELISA1:10000
Tested Application WB,ELISA;WB:1:500-10000,ELISA:1:10000
Datasheet
Western Blotting(WB) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10543312 CSB-PA146432 100μg $168.78
Add to Cart
BHA10543312 CSB-PA146432 50μg $123
Add to Cart