Mouse Anti-Human LRRK2/Dardarin Monoclonal IgG2a

Mfr.No.	SMC-445, SMC-445D, SMC-445D-A390, SMC-445D-A488, SMC-445D-A594, SMC-445D-ALP, SMC-445D-APC, SMC-445D-BI, SMC-445D-FITC, SMC-445D-HRP, SMC-445D-PCP, SMC-445D-RPE, SMC-445S
Immunogen Species	Human
Alternative Names	Leucine-rich repeat kinase 2 Antibody, RIP7 Antibody, PARK8 Antibody, Dardarin Antibody, ROCO 2 Antibody, RIPK7 Antibody, Leucine-rich repeat serine/threonine-protein kinase 2 Antibody, augmented in rheumatoid arthritis 17 Antibody
Categories	Antibodies
Cellular Localization	Endoplasmic Reticulum, Cytoplasm, Membrane, Mitochondrion, Golgi Apparatus, Cell Projection, Axon, Dendrite, Cytoplasmic Vesicle, Endosome, Lysosome
Certificate Of Analysis	10 ug/ml of SMC-445 was sufficient for detection of LRRK2/Dardarin in 20 ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Human LRRK2/Dardarin Monoclonal IgG2a
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1., Homo Sapiens (Human)
Immunogen Region	Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.
Isotype	IgG2a
Launch Date	2013/09/26
Net Weight (g)	0.1
Reactivity	Rat, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Rat, Human

Swissprot	Q5S007
Accession Number	NP_940980
Gene Id	120892
Target	LRRK2
Clone No	S231B-34
Research Area	Multiple System Atrophy, Neurodegeneration, Parkinson's Disease, Cell Signaling, Post-translational Modifications, Phosphorylation, Neuroscience

Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects >200kDa.
Storage	-20ºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11904362-1	SMC-445D	Unconjugated	100 ug	$330	Add to Cart
BHA11904362-2	SMC-445D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11904362-3	SMC-445D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11904362-4	SMC-445D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11904362-5	SMC-445D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11904362-6	SMC-445D-APC	APC	100 ug	$382	Add to Cart
BHA11904362-7	SMC-445D-BI	Biotin	100 ug	$378	Add to Cart
BHA11904362-8	SMC-445D-FITC	FITC	100 ug	$374	Add to Cart
BHA11904362-9	SMC-445D-HRP	HRP	100 ug	$370	Add to Cart
BHA11904362-10	SMC-445D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11904362-11	SMC-445D-RPE	RPE	100 ug	$380	Add to Cart
BHA11904362-12	SMC-445S	Unconjugated	12 ug	$44	Add to Cart

LRRK2/Dardarin Antibody, Clone S231B-34 - SMC-445

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