Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.Okano I., J. Biol. Chem. 270:31321-31330(1995).Osada H., Biochem. Biophys. Res. Commun. 229:582-589(1996).Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004)
Host
Rabbit
Immunogen
Synthesized non-phosphopeptide derived from Human LIMK2 around the phosphorylation site of serine 283 (R-R-S(p)-L-R).
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
Okano I., J. Biol. Chem. 270:31321-31330(1995). Osada H., Biochem. Biophys. Res. Commun. 229:582-589(1996). Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total LIMK2 protein.
Subcellular Location
Isoform LIMK2a: Cytoplasm, Nucleus, Note=Isoform LIMK2a is distributed in the cytoplasm and the nucleus, SUBCELLULAR LOCATION: Isoform LIMK2b: Cytoplasm, Nucleus
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
Pathway
Regulation of actin cytoskeleton Fc gamma R-mediated phagocytosis
Protein Families
Protein kinase superfamily, TKL Ser/Thr protein kinase family
Tissue Specificity
Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung,
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.